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Publications

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  1. Riley SP*, Fish AI. Del Piero F, Martinez JJ. “Immunity Against the Obligate Intracellular Bacterial Pathogen Rickettsia australis Requires Functional Complement System.” Infection Immun. 2018. 2018 May 22;86(6)
    Determined the contribution of different immune components to fighting Rickettsia infection. 
     

  2. Riley SP*, Pruneau L, Martinez JJ.  “Evaluation of Changes to the Rickettsia rickettsii Transcriptome During Mammalian Infection.” PLoS One. 2017 Aug 23;12(8):e0182290.
    Determine how Rickettsia rickettsii changes itself within the infected animal.
     

  3. Riley SP, Fish AI, Garza DG, Banajee KH, Harris EK, del Piero F, Martinez JJ. “Non-selective Persistence of a Rickettsia conorii Exogenous Plasmid During Fatal Mammalian Infection.” Infect Immun. 2016 Jan 11;84(3):790-7.
    Made green-and red-fluorescent Rickettsia conorii, showed fluorescent bacteria within the mammal, identified new host cell types that are parasitized by Rickettsia conorii. 
     

  4. Riley SP, Cardwell MM, Chan YGY, Pruneau L, del Piero F, Martinez JJ. “Failure of a Heterologous Recombinant Sca5/OmpB protein Based Vaccine to Elicit Effective Protective Immunity Against Rickettsia rickettsii Infections in C3H/HeN Mice.” Pathog Dis. 2015 Dec;73(9).
    Created a OmpB-based Rickettsia vaccine, demonstrated that it worked in R. conorii models of infection, but did not protect against R. rickettsii infection.
     

  5. Riley SP*, Macaluso KR, Martinez JJ.  “Electrotransformation and Clonal Propagation of Rickettsia species.”  In Current Protocols in Microbiology. Gallagher S and Wiley E (Ed.) J. Wiley and Sons, Hoboken, N.J. 2015. 39:3A.6.1-3A.6.20
    Protocol for inserting DNA into Rickettsia and isolating identical populations. 
     

  6. Czyz DM, Potluri L-P, Jain-Gupta N, Riley SP, Martinez JJ, Steck TL, Crosson S, Shuman HA, Gabay JE. 2014. “Host-directed Antimicrobial Drugs with Broad-spectrum Efficacy Against Intracellular Bacterial Pathogens.” mBio. 2014 Jul29;5(4):e01534-14.
    Big study with multiple labs that identified new drugs that can be used to fight intracellular bacteria. 
     

  7. Riley SP, Patterson JL, Nava S, Martinez JJ. “Pathogenic Rickettsia Species Acquire Vitronectin from Human Serum to Promote Resistance to Complement-mediated Killing.” Cell Microbiol. 2013 Jun;16(6):849-61.
    Rickettsia coats itself with a host protein that masks the bacteria from the immune system.

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